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The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans

โœ Scribed by Honig, Peter K; Wortham, Dale C; Zamani, Kaveh; Mullin, James C; Conner, Dale P; Cantilena, Louis R

Book ID
109845313
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
533 KB
Volume
53
Category
Article
ISSN
0009-9236

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Effect of concomitant administration of cimetidine and ranitidine on the pharmacokinetics and electrocardiographic effects of terfenadine
โœ P. K. Honig; D. C. Wortham; K. Zamani; D. P. Conner; J. C. Mullin; L. R. Cantile ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Springer ๐ŸŒ English โš– 628 KB

Terfenadine is a widely prescribed non-sedating antihistamine which undergoes rapid and almost complete first pass biotransformation to an active carboxylic acid metabolite. It is unusual to find unmetabolised terfenadine in the plasma of patients taking the drug. Terfenadine in vitro is a potent bl