The effect of extracellularly applied divalent cations on cytosolic Ca2+ in murine Leydig cells: evidence for a Ca2+-sensing receptor

Activation of the Ca2+ “receptor” on the

Activation of the Ca2+ “receptor” on the osteoclast by Ni2+ elicits cytosolic Ca2+ signals: Evidence for receptor activation and inactivation, intracellular Ca2+ redistribution, and divalent cation modulation

✍ Vijai S. Shankar; Christopher M. R. Bax; Bridget E. Bax; A. S. M. Towhidul Alam; 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 1011 KB

Earlier studies have demonstrated that a high (mM) extracellular CaL+ concentration triggers intracellular [Ca"] signals with a consequent inhibition of bone resorptive activity. We now report that micromolar concentrations of the divalent cation, Ni'+, elicited rapid and concentration-dependent ele