## Abstract Disc degeneration is associated with several changes in the physicochemical environment of intervertebral disc cells. Nucleus pulposus (NP) cells in the center of degenerated discs are exposed to decreased glucose supply, osmolarity, pH, and oxygen levels. To understand the complexity o
β¦ LIBER β¦
The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus
β Scribed by Sajjad Razaq; Robert J. Wilkins; Jill P. G. Urban
- Book ID
- 106190094
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 285 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0940-6719
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## Abstract Intervertebral disc and especially nucleus pulposus is characterized by low cellularity. Additionally, extreme variations in osmolality are observed in this tissue, as a result of its specific physicochemical environment, daily activities, or degeneration. In this study, we investigated