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The effect of dopamine administration on the activity of the renin-angiotensin-aldosterone system in sick preterm infants

✍ Scribed by E. Sulyok; I. Seri; T. Tulassay; J. Kiszel; T. Ertl

Publisher
Springer
Year
1985
Tongue
English
Weight
312 KB
Volume
143
Category
Article
ISSN
0340-6997

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✦ Synopsis

Nine premature infants with birth weight of 1150 to 2500 g and gestational age of 28 to 35 weeks were given dopamine in a dose of 2-4 gg/kg/min to treat cardiopulmonary distress.

In addition to monitoring of blood gases, blood pressure, acid-base balance, urine flow and urinary sodium excretion, plasma renin activity (PRA) and plasma aldosterone concentration (PA) was also determined prior to and during dopamine therapy.

The dopamine-induced increase in urine flow and urinary sodium excretion was associated with a significant increase of PRA from 18.2 _+ 5.1 n g/ml/h to 33.0 + 5.6 ng/ml/h (P < 0.025), while PA and blood pressure remained unaltered by dopamine administration.

It is suggested that the angiotensin II-stimulated aldosterone production is overridden by the inhibitory effect of dopamine.

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