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The effect of DOPA and clonidine on reflex pathways from group II muscle afferents to α-motoneurones in the cat

✍ Scribed by E. D. Schomburg; H. Steffens


Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
476 KB
Volume
71
Category
Article
ISSN
0014-4819

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✦ Synopsis


In high spinal cats the transmission in both disynaptic and polysynaptic reflex pathways from group II muscle afferents to motoneurones was effectively depressed by DOPA and clonidine together with an often less pronounced depression of transmission in other FRA reflex pathways. The inhibitory effect of both drugs on the inhibitory group II and FRA pathways was generally less distinct than that on the excitatory ones. The results are in agreement with former observations which suggested that the excitatory and the inhibitory FRA pathways are independently controlled by descending pathways from the brain stem (Holmqvist and Lundberg 1961).


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## Abstract The morphology of 12 sacral interneurones with peripheral input from group II muscle afferents was analyzed after intracellular injection of horseradish peroxidase (HRP). The neurones were located in Rexed's laminae III–V overlying the pudendal (Onuf's) motor nucleus. The interneurones