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The effect of displacement from protein binding on serum and tissue fluid levels of cephazolin

✍ Scribed by I. Polacek; H. Mühlbauer

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
322 KB
Volume
1
Category
Article
ISSN
0142-2782

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✦ Synopsis

Abstract

Displacement of cephazolin, a highly protein‐bound β‐lactam antibiotic, by sulpha‐phenazole was studied in vitro and in vivo. In vitro, the sulphonamide was effective in displacing the antibiotic from its binding sites at the concentration 100–1000 μmol I^−1^. In vivo, both the serum and the tissue fluid concentration of free cephazolin increased significantly in rats concomitantly treated with sulphaphenazole.

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