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The effect of disease states on serum protein binding of antimicrobials

✍ Scribed by W. A. Craig

Book ID
105274308
Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
679 KB
Volume
4
Category
Article
ISSN
0300-8126

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The possible acylating effects of cefotaxime on sulfisoxazole binding to serum proteins were evaluated in vitro in samples of human sera incubated with 50-1000 pg ml-l cefotaxime at 37" for 1 h and then dialyzed against saline. This incubation resulted in concentration-related increases in the free