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The effect of digitalization on quinidine toxicity

✍ Scribed by M. Brandfonbrener; C. Kjobech; E. Cooper

Book ID: 115653213
Publisher: Elsevier Science
Year: 1968
Tongue: English
Weight: 250 KB
Volume: 76
Category: Article
ISSN: 1097-6744
DOI: 10.1016/0002-8703(68)90201-9

No coin nor oath required. For personal study only.

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We have studied the hypoalgesic effect of codeine (100 mg) after blocking the hepatic O-demethylation of codeine to morphine via the sparteine oxygenase (CYP2D6) by quinidine (200 mg). The study was performed in 16 extensive metabolizers of sparteine, using a double-blind, randomized, four-way, cros