The effect of different lipid based formulations on the oral absorption of lipophilic drugs: The ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats

Use of in vitro lipid digestion data to

Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Studies with halofantrine

✍ Christopher J.H. Porter; Ann Marie Kaukonen; Agnes Taillardat-Bertschinger; Ben 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB 👁 1 views

The relative oral bioavailability (BA) of halofantrine base (Hf) was assessed in male beagle dogs after administration of a medium chain triglyceride (MCT), a long chain triglyceride (LCT), and a blended LCT/MCT lipid solution formulation of Hf (Study 1) and after administration of suspensions of Hf