The effect of dietary folate on p53 mutations in the dimethylhydrazine rat model of colon cancer
β Scribed by Kim, Y.I.; Puchyr, M.; Medline, A.; Salomon, R.N.; Graeme-Cook, F.; Choi, S.W.; Mason, J.B.
- Book ID
- 123079466
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 171 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0016-5085
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Mutations in the Ki-ras oncogene and the p53 tumor suppressor gene are known to occur at high frequencies in human colon cancers. We measured the frequency of mutations in these two genes in colon adenocarcinomas obtained from a widely used experimental model of human colon carcinogenesis: F344 rats
## Abstract Some studies have reported that __p53__ mutations or certain types of __p53__ mutation are associated with poor prognosis in colon cancer, while other studies have failed to show such a relationship. None of these previous studies was populationβbased. We therefore evaluated the prognos