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The effect of D-penicillamine on pulmonary findings in systemic sclerosis

✍ Scribed by Virginia D. Steen; Gregory R. Owens; Carol Redmond; Thomas A. Medsger Jr.

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
648 KB
Volume
28
Category
Article
ISSN
0004-3591

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D-penicillamine has been used to treat systemic sclerosis (scleroderma) for nearly two decades. Improvement in cutaneous fibrosis in patients treated with this drug has been documented in a number of uncontrolled studies (1). The effect of D-penicillamine on established visceral involvement due to s

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## Abstract Treatment of patients with D‐penicillamine (D‐P) has been associated with a syndrome similar to myasthenia gravis (MG). To explore this association, we examined the effects of D‐P on neuromuscular transmission in rat muscle. In the first experiment, bath‐applied D‐P had no significant e