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The effect of cyclic nucleotides on DNA polymerase, thymidylate synthetase, thymidine kinase and deoxynucleoside levels of Walker carcinoma

✍ Scribed by Michael J. Tisdale


Book ID
113136219
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
591 KB
Volume
30
Category
Article
ISSN
0009-2797

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The inhibitors of DNA synthesis, 5-fluoro-2'-deoxyuridine and hydroxyurea, caused an inhibition of thymidine kinase, replicative DNA polymerase and CDP reductase activities in stimulated lymphocytes when they were exposed to the inhibitors during the early transformation period (0-17 hr). However, t