The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats

✍ Scribed by Jeandre Augusto dos Santos Jaques; João Felipe Peres Rezer; Jamile Fabbrin Gonçalves; Rosélia Maria Spanevello; Jessié Martins Gutierres; Victor Câmera Pimentel; Gustavo Roberto Thomé; Vera Maria Morsch; Maria Rosa Chitolina Schetinger; Daniela Bitencourt Rosa Leal

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 232 KB
• Volume: 29
• Category: Article
• ISSN: 0263-6484
• DOI: 10.1002/cbf.1804

✦ Synopsis

With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'-nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke-exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12Á5, 25 and 50 mgÁkg -1 ; those in the second set were vehicle, smoke, smoke and Cur 12Á5, 25 and 50 mgÁkg -1 . Curcumin prevented the increased NTPDase, 5'-nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission.