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The effect of cotrimoxazole on the absorption of orally administered 6-mercaptopurine in the rat

โœ Scribed by Neil K. Burton; G. Wynne Aherne


Publisher
Springer
Year
1986
Tongue
English
Weight
169 KB
Volume
16
Category
Article
ISSN
0344-5704

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The industrial chemical 1,6-Hexane Diamine, or hexamethylenediamine (HMD), has an acute oral LD50 of 980 mg kg-1 in rats. Dietary administration of HMD to groups of rats for 3 months at dosages of 0, 50, 150, and 500 mg kg-1 resulted in a modest retardation in weight gain at the two higher test leve