The effect of context on the folding of β-hairpins
✍ Scribed by Amanda L. Jonsson; Valerie Daggett
- Book ID
- 116697178
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 973 KB
- Volume
- 176
- Category
- Article
- ISSN
- 1047-8477
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The importance of b-peptides lies in their ability to mimic the conformational behavior of a-peptides, even with a much shorter chain length, and in their resistance to proteases. To investigate the effect of substitution of b-peptides on their dominant fold, we have carried out a molecular-dynamics
Folding of beta-hairpin structures of synthetic peptides has been simulated using the molecular dynamics method with a solvent-referenced potential. Two similar sequences, Ac-MQIFVKS(D)PGKTITLKV-NH(2) and Ac-MQIFVKS(L)PGKTITLKV-NH(2), derived from the N-terminal beta-hairpin of ubiquitin, were used