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The effect of COMT inhibition with entacapone on cardiorespiratory responses to exercise in patients with Parkinson's disease

✍ Scribed by J. Lyytinen; S. Kaakkola; A. Gordin; E.-R. Kultalahti; H. Teräväinen; A. Sovijärvi

Book ID
117751777
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
104 KB
Volume
8
Category
Article
ISSN
1353-8020

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Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease
✍ V. V. Myllylä; K. A. Sotaniemi; A. Illi; K. Suominen; T. Keränen 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 563 KB

In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari