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The effect of clonidine and bright light on plasma melatonin

✍ Scribed by P. M. Grasby; P. J. Cowen

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 332 KB
Volume: 3
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470030107

No coin nor oath required. For personal study only.

✦ Synopsis

We studied the effect of the az-adrenoceptor agonist, clonidine, and bright artificial light (>2500 lux) on the nocturnal increase in plasma melatonin in normal subjects. Clonidine (1.5 pg/ kg, intravenously) was without effect on plasma melatonin concentration. In contrast, bright light treatment abolished the increase in night-time melatonin. Bright light is a simple and effective means of altering melatonin secretion in humans.

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