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The effect of cimetidine and ranitidine on paracetamol glucuronidation and sulphation in cultured rat hepatocytes

✍ Scribed by S. Emery; H.G. Oldham; S.J. Norman; R.J. Chenery

Book ID
115778560
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
548 KB
Volume
34
Category
Article
ISSN
0006-2952

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Cimetidine and ranitidine absorption were studied in rats, alone or in combination with concurrent but separate bupropion oral admininstration. Blood samples were collected before and 0.25, 0.5, 0.75, 1.0, 1-5, 2.0, 3.0, 4.5, and 6.0 h after dosing. In ranitidinetreated rats, an exta blood sample at