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The effect of ciclotropium on human heart rate

✍ Scribed by R. W. Ding; R. E. Port; K. Ortmann; B. Liebmann; H. Spahn-Langguth; E. Mutschler; E. Weber

Publisher: Springer
Year: 1994
Tongue: English
Weight: 404 KB
Volume: 46
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00191911

No coin nor oath required. For personal study only.

✦ Synopsis

Ciclotropium is a recently developed parasympathicolytic agent, Plasma concentration and heart rate increase (the most prominent anticholinergic effects) were measured in 12 healthy subjects before, during and after a 15-min intravenous infusion of 10 mg ciclotropium. The effect was described by using either a linear or a nonlinear (Em~0 effect model linked to a linear three-compartment kinetic model via an effect compartment.

Maximum heart rate increase was 33 (10) beats, rain 2, and half-value duration of effect was 41 (9)rain. Total plasma clearance was 0.51 (0.13) 1-rain 1, and mean terminal elimination half-life was 12 (4) h, whereas the equilibration half-lives of drug removal from the effect compartment ranged from 2 to 14 rain.

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