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The effect of chronic lithium administration on dopamine metabolism in rat striatum

✍ Scribed by J. E. Hesketh; N. M. Nicolaou; G. W. Arbuthnott; A. K. Wright

Publisher
Springer
Year
1978
Tongue
English
Weight
332 KB
Volume
56
Category
Article
ISSN
0033-3158

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✦ Synopsis

Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentration after 3 weeks of lithium administration. There was no change in tyrosine hydroxylase activity after 1, 2, and 3 weeks treatment. The results indicate an increase in the release and turnover of dopamine in the lithium-treated animals.

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