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The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels

โœ Scribed by S. N. Young; S. Gauthier; G. Chouinard; G. M. Anderson; W. C. Purdy

Publisher
Springer
Year
1982
Tongue
English
Weight
255 KB
Volume
53
Category
Article
ISSN
1435-1463

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Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in