The Effect of Anticonvulsant Drugs on Blood Levels of Methotrexate

✍ Scribed by Maurizio Riva; Giuseppe Landonio; Carlo Alberto Defanti; Salvatore Siena

• Book ID: 110235053
• Publisher: Springer US
• Year: 2000
• Tongue: English
• Weight: 17 KB
• Volume: 48
• Category: Article
• ISSN: 0167-594X
• DOI: 10.1023/a:1006404825356

✦ Synopsis

The reduced bioavailability of chemotherapeutic agents is one of the reasons that explains the limited efficacy of adjuvant chemotherapy in high grade glioma patients. We report how even the results of high dose sequential chemotherapy can be influenced by antiepileptic drugs.