Aminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoform (iNOS). In addition to being an inhibitor of NOS, aminoguanidine also exhibits antioxidant activity. Recent studies suggest that aminoguanidine reduces ischaemia-reperfusion (I/R)-induced d
The effect of aminoguanidine against cholestatic liver injury in rats
✍ Scribed by Mehmet Yilmaz; Cengiz Ara; Burak Isik; Neşe Karadag; Sezai Yilmaz; Alattin Polat; Sacit Coban; Halil Duzova
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 293 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0263-6484
- DOI
- 10.1002/cbf.1359
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## Abstract __Nigella sativa__ (NS) has been shown to have antioxidant and antiinflammatory activities in different conditions. The goal of this study was to evaluate the effects of NS on cholestatic liver injury in rats. Thirty rats were recruited in the study as follows: Group 1, Bile duct ligati