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The effect of age at diagnosis on outcome in rhabdomyosarcoma

✍ Scribed by Michael P. La Quaglia; Glenn Heller; Fereshteh Ghavimi; Ephraim S. Casper; Vaia Vlamis; Steven Hajdu; Murray F. Brennan

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 748 KB
Volume: 73
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19940101)73:1<109::aid-cncr2820730120>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Survival for rhabdomyosarcoma appears to be more favorable in children and adolescents compared with adults. To determine the significance of age at diagnosis as a prognostic indicator in rhabdomyosarcoma, we performed a retrospective analysis of a combined pediatric and adult rhabdomyosarcoma data base.

Methods. Pertinent prognostic variables, including age, TNM stage, histopathologic subtype, anatomic site, resectability, radiation to the primary site, and dose intensity of chemotherapy, were compared in a Cox proportional hazards model with mortality as the outcome variable.

Results. Age at diagnosis ( P = 0.0001) and local tumor invasiveness (P < O.OOO~), distant parenchymal metastases ( P < o.oool), regional lymph node involvement ( P = 0.0027), and histopathologic subtype (P = 0.0446) contributed information to the proportional hazards model.

Conclusions. Age at diagnosis is an independent predictor of outcome in patients with rhabdomyosarcoma along with tumor invasiveness, metastases, regional lymph node involvement, and histopathologic subtype. Cancer 1994; 73:109-17.

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