✦ LIBER ✦

The effect of adenine nucleotides on the rate and fate of glutamine utilization by incubated mitochondria isolated from rat mesenteric lymph nodes

✍ Scribed by Rui Curi; Eric A. Newsholme

Publisher: Springer
Year: 1989
Tongue: English
Weight: 367 KB
Volume: 86
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00231691

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✦ Synopsis

The rate of glutamine utilization by isolated lymphocyte mitochondria is 21.4 nmol/min per mg protein, of which 72% is converted to glutamate. Addition of ATP, ADP or AMP increased the rate of glutamine utilization by 60%. Evidence is presented that this is due to a stimulation of oxoglutarate dehydrogenase activity by ADP: this may account for the stimulation of glutamine utilization by concanavalin A in lymphocyte.