The effect of activated charcoal on mouse sleep times induced by intravenously administered hypnotics
✍ Scribed by Lauri J. Adler; Donald H. Waters; Peter R. Gwilt
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 416 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0142-2782
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✦ Synopsis
The effect of orally administered activated charcoal (AC) on the sleep times of mice following intravenous injection of various hypnotics was investigated. Preliminary studies with phenobarbital (Pb) showed that a linear relationship exists between the Pb-induced sleep time and the logarithm of the Pb dose in both control and AC treated mice. Half-lives of Pb in the two groups were estimated to be 8.1 and 0.9 h, respectively. A linear decline in Pb-induced sleep time with increasing dose of AC was observed up to a maximum effective dose of AC beyond which dose increments caused no further reduction in sleep time. A similar relationship was observed between sleep time and the concentration of sodium sulfate in which the AC was suspended. AC treatment resulted in an 82-88 per cent reduction in sleep time induced by administration of phenobarbital, methyprylon, glutethimide, ethchlorvynol, and methaqualone. AC had no significant effect on sleep time following amobarbital or pentobarbital administration.