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The effect of acetylcholine and dopamine on the caudate spindle in cats

✍ Scribed by P. E. Keane; R. C. Hall

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
400 KB
Volume
3
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Electrocortical activity was recorded in cats whose caudate nuclei were perfused and electrically stimulated using a push‐pull cannula. Electric stimulation invariably induced spindles (10β€”14Hz) in the ipsilateral frontal cortex. Perfusions of acetylcholine together with physostigmine reduced the number of spontaneous spindles, the response to electric stimulation and induced behavioural arousal. This effect was atropine‐sensitive. Perfusions of dopamine with or without tranylcypromine had no significant effect on the number of spontaneous to electric stimulation. Injections of both acetylcholine and dopamine into the cuadate nucleus invariably induced spontaneous spindles and slow waves. The significance of acetylcholine and dopamine in the caudate nucleus initiating caudate spindles and their significance in controlling arousal is discussed.

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