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The effect of a small dose of diethylcarbamazine on the circulation in the blood of microfilariae of W. bancrofti

✍ Scribed by P.E.C. Manson-Bahr; D.J.B. Wijers

Book ID
116055533
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
61 KB
Volume
66
Category
Article
ISSN
0035-9203

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To assess directly the effect of various doses of diethylcarbamazine (DEC) on adult Wchereria bancrofti, 3 1 infected men were randomly assigned to receive an initial single DEC dose of 1 mg/kg (n=7), 6 mg/kg (n= lo), or 12 mg/kg (n= 14). Beginning 7 d later, the dosage of DEC and duration of treatm

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When ivermectin and diethylcarbamazine (DEC) are given simultaneously in a single dose to persons with Wkhereria bancrofi infection, the resulting suppression of microfilaraemia is more profound and sustained than when either drug is given alone. To assess whether this effect is a result of enhanced