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The effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic side effects: In vivo and in vitro studies

โœ Scribed by ICHIRO IEIRI; WATARU GOTO; KENTARO HIRATA; AKITO TOSHITANI; SHUHEI IMAYAMA; YUKIKO OHYAMA; HIROAKI YAMADA; KENJI OHTSUBO; SHUN HIGUCHI


Book ID
118709230
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
397 KB
Volume
49
Category
Article
ISSN
1323-1316

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Effect of 5-(p-hydroxyphenyl)-5-phenylhy
โœ I. Ieiri; W. Goto; S. Higuchi; K. Hirata; A. Toshitani; S. Imayama; Y. Ohyama; H ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Springer ๐ŸŒ English โš– 571 KB

The purpose of this study was to assess the possible role of the (R)-and (S)-enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in