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The effect of 3′-deoxyadenosine N1-oxide on growth in vitro and in vivo on Ehrlich ascites tumor and on a human squamous lung cell carcinoma xenograft in nude mice


Book ID
122449049
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
135 KB
Volume
15
Category
Article
ISSN
0169-5002

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Synergistic effect of 3′-deoxyadenosineN
✍ Karsten Ramløv Svendsen; Kay Overgaard-Hansen; Sune Frederiksen 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 549 KB

The simultaneous administration of 3'-deoxyadenosine N1-oxide (3'-dANO) and the adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) or 2'-deoxycoformycin (2'-dCF) to mice bearing Ehrlich ascites tumor cells resistant to 3'-dANO resulted in 80%-90% inhibition of tumor growth i