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The effect of 2,4-dichlorophenol on growth and plasmidic β-lactamase activity in Escherichia Coli

✍ Scribed by M. Espigares; A. Mariscal

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
251 KB
Volume
9
Category
Article
ISSN
0260-437X

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✦ Synopsis

The toxic effects of 2,4-dichlorophenol on two strains of Escherichia coli harbouring plasmids with p-lactamase activity were studied. The toxicant had a significant effect on growth at concentrations of 12 p g mi-' for the JA 221 (pBR322) strain, as well as at 24 pg rnl-' for the 55-3 (RP4) strain. P-Lactamase production was affected at concentrations of 96 p g ml in both strains. However, P-lactamase production does not seem to constitute a reliable toxicity test in view of its variability and relatively low sensitivity.

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