The EcoRI rflp of c-MOS in patients with non-Hodgkin's lymphoma and acute lymphoblastic leukemia, compared to geriatric and non-Geriatric controls
✍ Scribed by G. Chenevix-Trench; M. Southall; C. Kidson
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 407 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
NON-GERIATRIC CONTROLS
We have used Southern blot analysis to type individuals for the presence or absence of a rare EcoRl RFLP at the c-mos proto-oncogene locus. This polymorphism has previously been reported to be associated with cancer. Ninety-eight patients with non-Hodgkin's lymphoma (NHL) or acute lymphoblastic leukemia (ALL) and I54 cancer-free individuals, including 108 geriatric patients with no family history of cancer, were studied. Because 4 geriatric patients (aged 67-94) were found to have the rare c-mos allele (AZ), and the frequency of this A2 allele was no higher among the IymphomaAeukemia patients than among cancer-free individuals, it is unlikely that it constitutes a marker for NHL or ALL.