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The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models

✍ Scribed by H. S. White; M. Johnson; H. H. Wolf; H. J. Kupferberg

Publisher
Springer Milan
Year
1995
Tongue
English
Weight
413 KB
Volume
16
Category
Article
ISSN
1590-1874

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This study evaluated the anticonvulsant activity of D-cycloserine against maximal electroshock seizures in rats. Systematically administered D-cycloserine (i.p.) inhibited maximal electroshock-induced tonic hindlimb extension in a dose-dependent manner with an ED50 of 153 mg/kg. No neurological defi