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The E-cadherin–catenin complex in tumour metastasis: structure, function and regulation

✍ Scribed by I.R.G Beavon

Book ID
115547287
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
786 KB
Volume
36
Category
Article
ISSN
0959-8049

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Much progress has been made in identifying genes mutated during the development of colorectal carcinoma. Mutation of the APC gene in particular appears to be fundamental for colorectal tumour initiation. In contrast, loss of expression of E-cadherin appears to be a late event, which may be important