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The dynamic structure of the germinal center

✍ Scribed by Stephanie A Camacho; Marie H Kosco-Vilbois; Claudia Berek

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
762 KB
Volume
19
Category
Article
ISSN
0167-5699

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✦ Synopsis

Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.

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