The drug resistance proteins, multidrug resistance-associated protein and P-glycoprotein, do not confer resistance to Fas-induced cell death

Ritonavir induces P-glycoprotein express

Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line

✍ Michael D. Perloff; Lisa L. Von Moltke; James E. Marchand; David J. Greenblatt 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB

The present study characterized the response of P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP1) to chronic ritonavir (RIT) exposure by assessing increases in P-gp and MRP1 protein expression and activity. LS-180V intestinal carcinoma cells were exposed for 3 days to 1±100 mM