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The Double Role of the Endoplasmic Reticulum Chaperone Tapasin in Peptide Optimization of HLA Class I Molecules

โœ Scribed by C. M. Cabrera


Book ID
110861455
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
609 KB
Volume
65
Category
Article
ISSN
0300-9475

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Exogenous peptides enter the endoplasmic
โœ Jonathanโ€„M. Levitt; Deweyโ€„D. Howell; Johnโ€„R. Rodgers; Robertโ€„R. Rich ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 169 KB

MHC class I molecules assemble within the endoplasmic reticulum (ER) in complexes that include g 2-microglobulin ( g 2 m), the transporter associated with antigen processing (TAP) and several additional chaperones. Release of class I complexes from the ER is thought to require the binding of an appr