The dose effects of zopiclone

✍ Scribed by James K. Lamphere; Timothy A. Roehrs; Frank J. Zorick; Gail Koshorek; Thomas Roth

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 518 KB
• Volume: 4
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470040107

✦ Synopsis

The dose effects of zopiclone on sleep were studied in 12 subjects. Subjects who complained of insomnia and had their complaint verified by nocturnal polysomnography were included in the study. Four consecutive nights of adaptation and screening, while on placebo, were followed by six 3-night drug administration periods separated by a 4-day placebo washout period spent at home. Each of the subjects received placebo, 2.5,5.0,7.5, 10.0 or 15-0 mg of zopiclone administered in a double-blind, randomized, six-way Latin square design. Zopiclone at all doses significantly increased total sleep time and decreased latencies to sleep compared to placebo dose. Dose differences were found for total sleep time and wake during sleep with 5.0 mg and larger doses differing from 2.5 mg. No further improvement was produced by doses greater than 5.0 mg. Sleep staging effects changed in a dose-dependent fashion with the 7.5 mg and higher doses significantly different from both placebo and the 2.5 mg dose. In general, hypnotic effects leveled off at the 5 mg dose while sleep stage effects increased with higher doses.