𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication

✍ Scribed by Nuria Pastor; Inmaculada Domínguez; Manuel Luís Orta; Claudia Campanella; Santiago Mateos; Felipe Cortés

Book ID
119330379
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
499 KB
Volume
738-739
Category
Article
ISSN
0027-5107

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Catalytic inhibitors of topoisomerase II
Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187
✍ Ling Wang; David A. Eastmond 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

Merbarone is a catalytic inhibitor of topoisomerase II (topo II) that has been proposed to act primarily by blocking topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. In this study merbarone was used as a model compound to investigate the genotoxic effects of catalyt

Effects of the DNA topoisomerase II inhi
Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: Cell cycle arrest and induction of aneuploidy
✍ Morko Kallio; Jaana Lähdetie 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 559 KB

In order to clarify possible risks of aneuploidy induc-highest level of MN induction (5.8 MN/1000 spertion in germ cells by cancer chemotherapy we stud-matids, P õ 0.001) was observed in animals inied effects of a non complex-stabilizing DNA topo-jected 48 hours before the harvest, corresponding iso