✦ LIBER ✦

The DNA-damaging potential of tamoxifen in breast cancer and normal cells

✍ Scribed by Katarzyna Wozniak; Agnieszka Kolacinska; Maria Blasinska-Morawiec; Alina Morawiec-Bajda; Zbigniew Morawiec; Marek Zadrozny; Janusz Blasiak

Publisher: Springer-Verlag
Year: 2007
Tongue: English
Weight: 392 KB
Volume: 81
Category: Article
ISSN: 0340-5761
DOI: 10.1007/s00204-007-0188-3

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The influence of phorbol ester on the ef

The influence of phorbol ester on the effect of tamoxifen in breast cancer cells

✍ Kailin, Cai ;Daoda, Chen ;Guobin, Wang ;Xiaoming, Lu ;Jinhui, Zhang ;Yuan, Tian 📂 Article 📅 2001 🏛 Springer-Verlag 🌐 English ⚖ 204 KB

Downregulation of erbB3 abrogates erbB2-

Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells

✍ Bolin Liu; Dalia Ordonez-Ercan; Zeying Fan; Susan M. Edgerton; XiaoHe Yang; Ann 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 654 KB

## Abstract Receptor tyrosine kinase activity is essential for erbB2 (HER2/__neu__) promotion of breast carcinogenesis, metastasis and therapeutic resistance. erbB2 kinase can be activated by dimerization with another erbB receptor, most of which bind ligands. Of these, the erbB2/erbB3 heterodimer

Aminoflavone induces oxidative DNA damag

Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells

✍ Lancelot McLean; Ubaldo Soto; Keli Agama; Jawad Francis; Randi Jimenez; Yves Pom 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 409 KB 👁 1 views

## Abstract Aminoflavone (5‐amino‐2‐(4‐amino‐3‐fluorophenyl)‐6,8‐difluoro‐7‐methylchromen‐4‐one; AF; NSC 686288), a novel anticancer candidate agent, is undergoing clinical evaluation. AF induces DNA‐protein cross‐links (DPCs), γ‐H2AX phosphorylation, aryl hydrocarbon receptor (AhR) signaling, apop

The influence of growth factors on the p

The influence of growth factors on the proliferative potential of normal and primary breast cancer-derived human breast epithelial cells

✍ Stephen P. Ethier; Rochelle M. Summerfelt; Kimberly C. Cundiff; Bonnie B. Asch 📂 Article 📅 1991 🏛 Springer US 🌐 English ⚖ 833 KB

Role of GPR30 in the mechanisms of tamox

Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells

✍ Atanas Ignatov; Tanja Ignatov; Albert Roessner; Serban Dan Costa; Thomas Kalinsk 📂 Article 📅 2009 🏛 Springer US 🌐 English ⚖ 566 KB

Tamoxifen accelerates proteasomal degrad

Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells

✍ Ching-Chuan Kuo; Jin-Fen Liu; Her-Shyong Shiah; Li-Chen Ma; Jang-Yang Chang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 412 KB

## Abstract Tamoxifen, a synthetic triphenyl‐ethylene compound, is a member of a class of anticancer drugs known as selective estrogen receptor modulators. It may block tumor growth by mimicking estrogen and binding to the estrogen receptors, preventing cancerous growth. Clinical studies have demon