The distribution of glucocerebroside in the liver of patients with Gaucher's disease

✍ Scribed by Andrew E. Gal; Peter G. Pentchev; John A. Barranger; James M. Dambrosia; Roscoe O. Brady

• Publisher: Elsevier Science
• Year: 1979
• Tongue: English
• Weight: 446 KB
• Volume: 95
• Category: Article
• ISSN: 0003-2697
• DOI: 10.1016/0003-2697(79)90195-7

✦ Synopsis

Two Gaucher livers obtained at autopsy were examined for uniformity of glucocerebroside content. Six needle biopsies were obtained from one liver and twenty from the other. Samples were analyzed for glucocerebroside content by thin-layer and gas-liquid chromatography. One of the livers was partitioned into four sections with five biopsies taken at random from each section. This method supposes that if differences in glycolipid concentrations exist, then these differences will be exhibited among the liver sections. Our findings indicate that stored glucocerebroside is uniformly distributed throughout the liver since all the observed glycolipid levels were within 2 1.95 sample standard deviations of the sample mean.