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The distribution of dermal tumorigens in coal liquids: Relationship of tumorigenicity and microbial mutagenicity

✍ Scribed by J. M. Holland; F. W. Larimer; T. K. Rao; J. L. Epler; C.-H. Ho; M. V. Buchanan; M. R. Guerin

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
628 KB
Volume
4
Category
Article
ISSN
0260-437X

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✦ Synopsis

Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigencity differ from those responsible for mutagenicity.

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