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The distribution of [11C]cocaine in normal and cocaine-sensitization mice

✍ Scribed by Mizugaki, Michinao; Hishinuma, Takanori; Kimura, Katsuhiko; Nakamura, Hitoshi; Aso, Hisashi; Ishii, Fumio; Nishikawa, Masazumi; Itoh, Kunihiko; Tomioka, Yoshihisa; Ishiwata, Shunji; Moritani, Hiroshi; Uyama, Taizo; Ido, Tatsuo


Book ID
122375997
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
605 KB
Volume
21
Category
Article
ISSN
0969-8051

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The Ability of cocaine to block the dopamine transporter (DAT) in the nucleus accumbens, as well as its non-striatal and non-DAT actions, appears to be crucial for its reinforcing/rewardig effects. However, we have been unable to use PET and [11C]cocaine to map small regions with greater sensitivity

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We have previously shown that tracer concentrations of [llC]cocaine binding to the dopamine transporter (DAT) in human and baboon striatum can be visualized using positron emission tomography (PET). To determine whether the concentration of dopamine normally present in the synaptic cleft can compete