The dissociation rate of estrogen receptor-ligand complexes is increased by high concentrations of steroids and antiestrogens

A simple, rapid, and precise method for

A simple, rapid, and precise method for calculating the steroid hormone-receptor complex concentration in the presence of saturating levels of hormone by using “differential dissociation” techniques

✍ Hélène Richard-Foy; Gérard Redeuilh; Robert Richard-Foy 📂 Article 📅 1978 🏛 Elsevier Science 🌐 English ⚖ 799 KB

The steroid hormone-receptor complex concentrations measured by "differential dissociation" techniques have to be corrected to obtain the true concentrations of receptor binding sites (B,). For the calculation of B,, the parameters kn (product of the equilibrium association constant and the concentr