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The Disruption of Hepatic Cytochrome P450 Reductase Alters Mouse Lipid Metabolism

✍ Scribed by Mutch, David M.; Klocke, Bernward; Morrison, Peter; Murray, Carol A.; Henderson, Colin J.; Seifert, Martin; Williamson, Gary

Book ID
126028440
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
240 KB
Volume
6
Category
Article
ISSN
1535-3893

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## Abstract Summary: NADPH‐cytochrome P450 reductase (CPR or POR) is the obligatory electron donor for all microsomal cytochrome P450 (CYP or P450)‐catalyzed monooxygenase reactions. Disruption of the mouse __Cpr__ gene has been reported to cause prenatal developmental defects and embryonic lethali