Hepatic disposition of the cytochrome P4
β
Reza Mehvar; Ragini Vuppugalla
π
Article
π
2006
π
John Wiley and Sons
π
English
β 178 KB
The steady-state disposition of chlorzoxazone (CZX) and its hydroxylated metabolite 6-hydroxychlorzoxazone (HCZX) was determined in a single-pass isolated perfused rat liver (IPRL) model using constant CZX concentrations of 10-200 microM. The concentrations of CZX, HCZX, and/or HCZX glucuronide in t