Effects of ibuprofen on the disposition
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Patricia A. Cleveland; Clarence T. Ueda
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Article
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1985
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John Wiley and Sons
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English
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The effects of ibuprofen on maternal phenytoin pharmacokinetics and fetal phenytoin acquisition were investigated in 19-day gestation Sprague-Dawley rats. A 5 mg kg-' bolus injection of I4C-phenytoin was given with and without (control) pretreatment with 12.5 mg kg-' of ibuprofen. Maternal plasma an