Estrogen (ER) and progesterone (PgR) receptors were assayed by histochemistry in primary, recurrent, and metastatic breast cancer. Ligand-conjugates composed of 17P-estradiol and 1 lcu-hydroxyprogesterone covalently linked to bovine serum albumin and labelled with fluorescein isothiocyanate were emp
The discrepancy between immunocytochemical and biochemical assay of estrogen receptor in breast cancer patients treated by endocrine therapy
β Scribed by Masakazu Toi; Takashi Nakamura; Tsutomu Wada; Atsushi Yamamoto; Tetsuya Toge; Minoru Niimoto; Takao Hattori
- Book ID
- 112756141
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 316 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1436-2813
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Histological sections obtained from 70 patients with breast cancer, all of whom had received endocrine therapy for metastatic or locally advanced disease, were assessed for specific immunocytochemical staining of oestrogen receptor and the oestrogen-induced protein pS2. There was also sufficient mat
## Abstract Glucocorticoid receptors have been detected in 90 human breast tumors and tumorβlike conditions by the immunoperoxidase method using a specific antibody against the glucocorticoid receptor isolated from rat thymocytes. In some of the specimens the [^3^H]βdexamethasone binding assay was
Evaluation of estrogen (ER) and progesterone (PR) receptor content is now an important procedure in the management of breast cancer patients. Production of monoclonal antibodies to ER and PR has permitted development of an enzyme immunoassay (EIA) and immunocytochemical assay (ICA). This study compa
This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (>3 fmoUmg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to