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The Discovery of Novel β-Secretase Inhibitors: Pharmacophore Modeling, Virtual Screening, and Docking Studies

✍ Scribed by Yan Niu; Chao Ma; Hongwei Jin; Fengrong Xu; Haifei Gao; Peng Liu; Yongjian Li; Chao Wang; Guanyu Yang; Ping Xu

Book ID: 114853998
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 423 KB
Volume: 79
Category: Article
ISSN: 1747-0277
DOI: 10.1111/j.1747-0285.2012.01367.x

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## Abstract The stem cell factor receptor (c‐Kit) has been known to play critical roles in regulating numerous aspects of cellular behavior including cell growth, differentiation, migration and metabolism. In this investigation, a three‐dimensional pharmacophore model of c‐Kit inhibitors has been e