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The discovery of diazepinone-based 5-HT3 receptor partial agonists

✍ Scribed by Manning, David D.; Guo, Cheng; Zhang, Zhenjun; Ryan, Kristen N.; Naginskaya, Jennifer; Choo, Sok Hui; Masih, Liaqat; Earley, William G.; Wierschke, Jonathan D.; Newman, Amy S.; Brady, Catherine A.; Barnes, Nicholas M.; Guzzo, Peter R.

Book ID
122282012
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
643 KB
Volume
24
Category
Article
ISSN
0960-894X

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## Abstract A 5‐HT~3~ receptor agonist based on a benzamide scaffold was identified in a screening of a small commercial compound library, and an elaborate SAR study originating from this hit was performed. The design, synthesis, and functional characterisation of benzamide analogues at the 5‐HT~3~